Assess patient taking anticoagulants for signs of bleeding and hemorrhage (bleeding gums; nosebleed; unusual bruising; tarry, black stools; hematuria; fall in hematocrit or blood pressure; guaiac-positive stools; urine; or NG aspirate).
Assess patient for evidence of additional or increased thrombosis. Symptoms will depend on area of involvement.
Monitor prothrombin time (PT) or international normalized ratio (INR) with warfarin therapy, activated partial thromboplastin time (aPTT) with full-dose heparin therapy and hematocrit, and other clotting factors frequently during therapy.
Monitor bleeding time throughout antiplatelet therapy. Prolonged bleeding time, which is time and dose dependent, is expected.
If overdose occurs or anticoagulation needs to be immediately reversed, the antidote for heparins is protamine sulfate; for warfarin, the antidote is vitamin K (phytonadione [AquaMEPHYTON]). Administration of whole blood or plasma may also be required in severe bleeding due to warfarin because of the delayed onset of vitamin K.
anticoagulants has been found in Davis's Drug Guide
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