Absorption: Well absorbed (90%) from the GI tract; absorption is slower with extended-release tablets.
Distribution: Widely distributed, crosses blood-brain barrier. Probably crosses the placenta and enters breast milk. Accumulation is minimal.
Metabolism and Excretion: Metabolized by the liver (CYP3A4 enzyme system) to an active compound that is subsequently rapidly metabolized.
Half-life: 1215 hr.
TIME/ACTION PROFILE (sedation)
|PO||12 hr||12 hr||up to 24 hr|