Contraindicated in:

• Hypersensitivity;
• Cross-sensitivity with other benzodiazepines may exist;
• Pre-existing CNS depression;
• Severe uncontrolled pain;
• Angle-closure glaucoma;
• Obstructive sleep apnea or pulmonary disease;
• Concurrent use with itraconazole or ketoconazole;
• OB: Lactation: Use in pregnancy or lactation may cause CNS depression, flaccidity, feeding difficulties, and seizures in infant.

Use Cautiously in:

• Renal impairment(↓ dose required);
• Hepatic impairment (↓ dose required);
• Concurrent use with nefazodone, fluvoxamine, cimetidine, fluoxetine, hormonal contraceptives, diltiazem, isoniazid, erythromycin, clarithromycin, or grapefruit juice (↓ dose may be necessary);
• History of suicide attempt or alcohol/drug dependence, debilitated patients (↓ dose required);
• Pedi: Safety and efficacy not established; ↓ dosage and frequent monitoring required;
• Geri: Appears on Beers list. Elderly patients have ↑ sensitivity to benzodiazepines; associated with ↑ risk of falls and excessive CNS effects (↓ dose required).