- Cross-sensitivity with other benzodiazepines may exist;
- Pre-existing CNS depression;
- Severe uncontrolled pain;
- Angle-closure glaucoma;
- Obstructive sleep apnea or pulmonary disease;
- Concurrent use with itraconazole or ketoconazole;
- OB: Lactation: Use in pregnancy or lactation may cause CNS depression, flaccidity, feeding difficulties, and seizures in infant.
Use Cautiously in:
- Renal impairment(↓ dose required);
- Hepatic impairment (↓ dose required);
- Concurrent use with nefazodone, fluvoxamine, cimetidine, fluoxetine, hormonal contraceptives, diltiazem, isoniazid, erythromycin, clarithromycin, or grapefruit juice (↓ dose may be necessary);
- History of suicide attempt or alcohol/drug dependence, debilitated patients (↓ dose required);
- Pedi: Safety and efficacy not established; ↓ dosage and frequent monitoring required;
- Geri: Appears on Beers list. Elderly patients have ↑ sensitivity to benzodiazepines; associated with ↑ risk of falls and excessive CNS effects (↓ dose required).
ALPRAZolam has been found in Davis's Drug Guide
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