Contraindicated in:

• Anuria;

• Active hepatitis.

• Underlying renal disease (dose reduction required if serum creatinine >2 mg/dL);

• Cardiac arrhythmias;

• OB: Lactation: Pregnancy or lactation (safety not established);

• Lead encephalopathy (should be used with concurrent dimercaprol);

• Geri: Geriatric patients (dose reduction may be necessary because of age-related decrease in renal function).