Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Protein Binding: 50% primarily to albumin.

Metabolism and Excretion: Metabolism of flumazenil occurs primarily in the liver.

Half-life: Children: 20–75 min; Adults: 41–79 min.

TIME/ACTION PROFILE (reversal of benzodiazepine effects)

ROUTE	ONSET	PEAK	DURATION
IV	1–2 min	6–10 min	1–2 hr†

†Depends on dose/concentration of benzodiazepine and dose of flumazenil