Concurrent use with aspirin may ↓ effectiveness.
Additive adverse GI effects with aspirin , other NSAIDs , corticosteroids , or alcohol .
Chronic use of acetaminophen ↑ risk of adverse renal reactions.
May ↓ effectiveness of diuretics or antihypertensives .
May ↑ hypoglycemia from insulins or oral hypoglycemic agents .
May ↑ risk of toxicity from lithium or zidovudine (avoid concurrent use with zidovudine).
↑ risk of toxicity from methotrexate .
Probenecid ↑ risk of toxicity from indomethacin.
↑ risk of bleeding with cefotetan , cefoperazone , valproic acid , thrombolytics , warfarin , and drugs affecting platelet function including clopidogrel , ticlopidine , abciximab , eptifibatide , or tirofiban .
↑ risk of adverse hematologic reactions with antineoplastics or radiation therapy .
↑ risk of nephrotoxicity with cyclosporine .
Concurrent use with potassium-sparing diuretics may result in hyperkalemia.
May ↑ levels of digitalis glycosides , methotrexate , lithium , and aminoglycosides when used IV in neonates.Drug-Natural Products
↑ bleeding risk with anise
, clove , dong quai
, Panax ginseng .
indomethacin has been found in Davis's Drug Guide
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