Drug-Drug

• Concurrent use with aspirin may ↓ effectiveness.

• Additive adverse GI effects with aspirin , other NSAIDs , corticosteroids , or alcohol .

• Chronic use of acetaminophen ↑ risk of adverse renal reactions.

• May ↓ effectiveness of diuretics or antihypertensives .

• May ↑ hypoglycemia from insulins or oral hypoglycemic agents .

• May ↑ risk of toxicity from lithium or zidovudine (avoid concurrent use with zidovudine).

• ↑ risk of toxicity from methotrexate .

• Probenecid ↑ risk of toxicity from indomethacin.

• ↑ risk of bleeding with cefotetan , cefoperazone , valproic acid , thrombolytics , warfarin , and drugs affecting platelet function including clopidogrel , ticlopidine , abciximab , eptifibatide , or tirofiban .

• ↑ risk of adverse hematologic reactions with antineoplastics or radiation therapy .

• ↑ risk of nephrotoxicity with cyclosporine .

• Concurrent use with potassium-sparing diuretics may result in hyperkalemia.

• May ↑ levels of digitalis glycosides , methotrexate , lithium , and aminoglycosides when used IV in neonates.

Drug-Natural Products
↑ bleeding risk with anise , arnica , chamomile , clove , dong quai , feverfew , garlic , ginger , ginkgo , Panax ginseng .