Absorption: Well absorbed following oral administration. Rapidly and completely absorbed following IM administration. Sublingual absorption is more rapid than oral and is similar to IM.
Distribution: Widely distributed. Crosses the blood-brain barrier. Crosses the placenta; enters breast milk.
Metabolism and Excretion: Highly metabolized by the liver.
Half-life: Full-term neonates: 1873 hr; Older children: 617 hr; Adults: 1016 hr.
TIME/ACTION PROFILE (sedation)
|PO||1560 min||16 hr||812 hr|
|IM||3060 min||12 hr||812 hr|
|IV||1530 min||1520 min||812 hr|
LORazepam has been found in Davis's Drug Guide
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