Nursing Central: LORazepam

LORazepam

Pharmacokinetics

Absorption: Well absorbed following oral administration. Rapidly and completely absorbed following IM administration. Sublingual absorption is more rapid than oral and is similar to IM.

Distribution: Widely distributed. Crosses the blood-brain barrier. Crosses the placenta; enters breast milk.

Metabolism and Excretion: Highly metabolized by the liver.

Half-life: Full-term neonates: 18–73 hr; Older children: 6–17 hr; Adults: 10–16 hr.

TIME/ACTION PROFILE (sedation)

ROUTE	ONSET	PEAK	DURATION
PO	15–60 min	1–6 hr	8–12 hr
IM	30–60 min	1–2 hr†	8–12 hr
IV	15–30 min	15–20 min	8–12 hr

†Amnestic response

LORazepam has been found in Davis's Drug Guide

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