• Conduct regular assessment of continued need for treatment.

• Pedi: Assess neonates for prolonged CNS depression related to inability to metabolize lorazepam.

• Geri: Assess geriatric patients carefully for CNS reactions as they are more sensitive to these effects. Assess falls risk.

• Assess degree and manifestations of anxiety and mental status (orientation, mood, behavior) prior to and periodically throughout therapy.

• Prolonged high-dose therapy may lead to psychological or physical dependence. Restrict amount of drug available to patient.

• Assess location, duration, characteristics, and frequency of seizures. Institute seizure precautions.

• Patients on high-dose therapy should receive routine evaluation of renal, hepatic, and hematologic function.

• If overdose occurs, flumazenil (Romazicon) is the antidote. Do not use with patients with seizure disorder. May induce seizures.