Conduct regular assessment of continued need for treatment.
Pedi: Assess neonates for prolonged CNS depression related to inability to metabolize lorazepam.
Geri: Assess geriatric patients carefully for CNS reactions as they are more sensitive to these effects. Assess falls risk.Anxiety
Assess degree and manifestations of anxiety and mental status (orientation, mood, behavior) prior to and periodically throughout therapy.
Prolonged high-dose therapy may lead to psychological or physical dependence. Restrict amount of drug available to patient.Status Epilepticus
Assess location, duration, characteristics, and frequency of seizures. Institute seizure precautions.Lab Test Considerations
Patients on high-dose therapy should receive routine evaluation of renal, hepatic, and hematologic function.Toxicity and Overdose
If overdose occurs, flumazenil (Romazicon) is the antidote. Do not use with patients with seizure disorder. May induce seizures.
LORazepam has been found in Davis's Drug Guide
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