Pharmacokinetics
Absorption: Minimal systemic absorption.
Distribution: Action is local, within the GI tract.
Protein Binding: Minimally absorbed drug is >99% bound to plasma proteins.
Metabolism and Excretion: Major route is fecal elimination of unabsorbed drug.
Half-life: 1–2 hr.
TIME/ACTION PROFILE (effects on fecal fat)
| ROUTE | ONSET | PEAK | DURATION |
| PO | 24–48 hr | unknown | 48–72 hr† |
†Following discontinuation
orlistat has been found in Davis's Drug Guide
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