Contraindicated in:

• Hypersensitivity;

• Comatose patients or those with pre-existing CNS depression;

• Severe respiratory disease with dyspnea or obstruction;

• Uncontrolled severe pain;

• Known alcohol intolerance (elixir only);

• Lactation: Discontinue drug or bottle feed.

• Hepatic dysfunction;

• Severe renal impairment;

• History of suicide attempt or drug abuse;

• Hypnotic use should be short-term. Chronic use may lead to dependence;

• OB: Chronic use during pregnancy results in drug dependency in the infant; may result in coagulation defects and fetal malformation; acute use at term may result in respiratory depression in the newborn;

• Geri: Initial dose ↓ recommended.