Davis's Drug Guide
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PHENobarbital

Route/Dosage

Status Epilepticus

IV (Adults and Children >1 mo): 15–18 mg/kg in a single or divided dose, maximum loading dose 20 mg/kg..

IV (Neonates): 15–20 mg/kg in a single or divided dose..

Maintenance Anticonvulsant

IV, PO (Adults and Children > 12 yr): 1–3 mg/kg/day as a single dose or 2 divided doses..

IV, PO (Children 5–12 yr): 4–6 mg/kg/day in 1–2 divided doses..

IV, PO (Children 1–5 yr): 6–8 mg/kg/day in 1–2 divided doses..

IV, PO (Infants): 5–6 mg/kg/day in 1–2 divided doses..

IV, PO (Neonates): 3–4 mg/kg/day once daily, may need to increase up to 5 mg/kg/day by 2nd week of therapy..

Sedation

PO, IM (Adults): 30–120 mg/day in 2–3 divided doses. Preoperative sedation—100–200 mg IM 1–1.5 hours before the procedure..

PO (Children): 2 mg/kg 3 times daily. Preoperative sedation—1–3 mg/kg PO/IM/IV 1–1.5 hours before the procedure..

Hypnotic

PO, SC, IV, IM (Adults): 100–320 mg at bedtime..

IV, IM, SC (Children): 3–5 mg/kg at bedtime..

Hyperbilirubinemia

PO (Adults): 90–180 mg/day in 2–3 divided doses..

PO (Children <12 yr): 3–8 mg/kg/day in 2–3 divided doses, doses up to 12 mg/kg/day have been used..

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