Davis's Lab & Diagnostic Tests
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Cholesterol, Total

Interfering Factors

  • Drugs that may increase cholesterol levels include amiodarone, androgens, β-blockers, calcitriol, cortisone, cyclosporine, danazol, diclofenac, disulfiram, fluoxymesterone, glucogenic corticosteroids, ibuprofen, isotretinoin, levodopa, mepazine, methyclothiazide, miconazole (owing to castor oil vehicle, not the drug), nafarelin, nandrolone, some oral contraceptives, oxymetholone, phenobarbital, phenothiazine, prochlorperazine, sotalol, thiabendazole, thiouracil, tretinoin, and trifluoperazine.
  • Drugs that may decrease cholesterol levels include acebutolol, amiloride, aminosalicylic acid, androsterone, ascorbic acid, asparaginase, atenolol, atorvastatin, beclobrate, bezafibrate, carbutamide, cerivastatin, cholestyramine, ciprofibrate, clofibrate, clonidine, colestipol, dextrothyroxine, doxazosin, enalapril, estrogens, fenfluramine, fenofibrate, fluvastatin, gemfibrozil, haloperidol, hormone replacement therapy, hydralazine, hydrochlorothiazide, interferon, isoniazid, kanamycin, ketoconazole, lincomycin, lisinopril, lovastatin, metformin, nafenopin, nandrolone, neomycin, niacin, nicotinic acid, nifedipine, oxandrolone, paromomycin, pravastatin, probucol, simvastatin, tamoxifen, terazosin, thyroxine, trazodone, triiodothyronine, ursodiol, valproic acid, and verapamil.
  • Ingestion of alcohol 12 to 24 hr before the test can falsely elevate results.
  • Ingestion of drugs that alter cholesterol levels within 12 hr of the test may give a false impression of cholesterol levels, unless the test is done to evaluate such effects.
  • Positioning can affect results; lower levels are obtained if the specimen is from a patient who has been supine for 20 min.
  • Failure to follow dietary restrictions before the procedure may cause the procedure to be canceled or repeated.

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