Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
Pronunciation:
seyj
Trade Name(s)
Ther. Class.
anti-Alzheimers's agents
anti-infectives
Sage leaf and volatile oil contain active constituents that have antioxidant, CNS depressant, estrogenic, anti-inflammatory and anticholinesterase activity. It may also have hypoglycemic activity. Sage also contains camphor which can cause neurotoxicity and hepatotoxicity in high doses.
Therapeutic Effect(s):
Improved cognitive function in Alzheimer's disease.
Absorption: Unknown
Distribution: Unknown
Metabolism and Excretion: Unknown
Half-life: Unknown
TIME/ACTION PROFILE
ONSET | PEAK | DURATION | |
---|---|---|---|
PO | unknown | unknown | unknown |
Contraindicated in:
Use Cautiously in:
CV: hypertension
CNS: dizziness, agitation, seizures (high doses)
GI: nausea, vomiting, abdominal pain, hepatotoxicity (high doses)
Resp: wheezing
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Natural Drug Interaction
Natural-Natural:
PO (Adults): Alzheimer's disease– 1 gram/day of extract.
Topical (Adults): Herpes labialis– apply cream with 23 mg/gram of sage extract every 2–4 hours while awake starting within 1 day of the first symptoms and continuing for 10 to 14 days.
Extract:
Cream : 23 mg/gram sage extract in combination with rhubarb extract
Lab Test Considerations:
Monitor: blood glucose periodically during therapy.
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