* CAPITALS indicate life-threatening. Underline indicate most frequent.
Should not be used concurrently with oral levothyroxine due to interference with phosphorous homeostasis.
May ↓ absorption and effectiveness of doxycycline; administer 1 hr before sucroferric oxyhydroxide.
PO (Adults) 500 mg 3 times daily (with meals) initially, may be titrated by 500 mg/day at weekly intervals depending on serum phosphorous; usual range is 1500–3000 mg/day in 3 divided doses.
Chewable tablets (wild berry-flavored): 500 mg
Monitor for abdominal pain or discomfort. Sucroferric oxyhydroxide causes discolored (black) stool and may mask GI bleeding. Medication does not effect guaiac based (Hemocult) or immunological based (iColoRectal and Hexagon Opti) fecal occult blood tests.
Lab Test Considerations: Monitor serum phosphorous levels and dose of sucroferric oxyhydroxide. Dose is titrated in increments of 500 mg (1 tablet) per day as needed until acceptable serum phosphorous level (≤5.5 mg/dL) is reached. Monitor periodically thereafter. May begin titration 1 wk after start of therapy and adjust at weekly intervals.
Monitor effect and iron homeostasis in patients with peritonitis during peritoneal dialysis, significant hepatic or gastric disorders, following major gastrointestinal surgery, or with a history of hemachromatosis or other diseases with iron accumulation.
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