Lactation: Doxylamine probably enters breast milk and may cause irritability, excitement, or sedation in infants; breast feeding should be avoided.
Use Cautiously in:
↑ intraocular pressure or narrow angle glaucoma
Stenosing peptic ulcer or pyloroduodenal obstruction
Urinary bladder-neck obstruction
Pedi: Safety and effectiveness not established
Adverse Reactions/Side Effects
* CAPITALS indicate life-threatening. Underline indicate most frequent.
↑ risk of CNS depression with other CNS depressants including alcohol, other antihistamines, opioid analgesics, and sedative/hypnotics.
Concurrent use of MAOIs ↑ intensity/duration of adverse CNS (anticholinergic) reactions
PO: (Adults)Day 1–2 tablets (doxylamine 10 mg/pyridoxine 10 mg) at bedtime, if symptoms are controlled continue this regimen; Day 2, if symptoms persist into afternoon on day 2–2 tablets at bedtime on day 2 and then 1 tablet in the morning on day 3 and 2 tablets in the evening, if symptoms are controlled, continue this regimen; Day 4, if symptoms persist–1 tablet in the morning, 1 tablet mid-afternoon and 2 tablets at bedtime (not to exceed four tablets daily).
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