lactitol

General

General

General

**Off Market Drug**
This medication is no longer available in the United States. Information provided here is for reference purposes only.

Pronunciation:
lak-ti-tol


Trade Name(s)

  • Pizensy

Ther. Class.

laxatives

Pharm. Class.

osmotics

Indications

Indications

Indications

Chronic idiopathic constipation.

Action

Action

Action

Acts as an osmotic agent, drawing water into the lumen of the GI tract.

Therapeutic Effect(s):

Increased complete, spontaneous bowel movements.

Pharmacokinetics

Pharmacokinetics

Pharmacokinetics

Absorption: Minimally absorbed following oral administration.

Distribution: Unknown.

Metabolism and Excretion: Excreted in fecal contents.

Half-life: 2.4 hr.

TIME/ACTION PROFILE (bowel movement)

ROUTEONSETPEAKDURATION
POunknownunknownunknown

Contraindication/Precautions

Contraindication/Precautions

Contraindication/Precautions

Contraindicated in:

  • GI obstruction;
  • Galactosemia.

Use Cautiously in:

  • OB:   Safety not established in pregnancy;
  • Lactation:  Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
  • Pedi:   Safety and effectiveness not established in children.

Adverse Reactions/Side Effects

Adverse Reactions/Side Effects

Adverse Reactions/Side Effects

CV: hypertension

GI: abdominal distention, abdominal pain, diarrhea, flatulence

GU: urinary tract infection

MS: ↑ creatine kinase

Resp: upper respiratory tract infection

* CAPITALS indicate life-threatening.
Underline indicate most frequent.

Interactions

Interactions

Interactions

Drug-Drug

May ↓ absorption and effectiveness of concurrently administered medications; administer other medications ≥2 hr before or after lactitol.

Route/Dosage

Route/Dosage

Route/Dosage

PO (Adults): 20 g once daily; ↓ to 10 g once daily if persistent, loose stools.

Availability

Availability

Availability

Powder: 280 g/bottle, 560 g/bottle

Assessment

Assessment

Assessment

  • Assess bowel sounds and frequency, quantity, and consistency of stools periodically during therapy.

Potential Diagnoses

Potential Diagnoses

Potential Diagnoses

  • Constipation (Indications) 

Implementation

Implementation

Implementation

  • PO Administer once daily with meals.
    • Multi-dose bottle: Use bottle cap to measure 10 g of powder. Fill twice for 20-g dose. Pour dose into empty 8 oz glass. Add 4 oz of water, juice or other beverage (coffee, tea, soda) and stir to dissolve. Drink entire contents of glass.
    • Administer oral medications at least 2 hr before or 2 hr after lactitol.

Patient/Family Teaching

Patient/Family Teaching

Patient/Family Teaching

  • Instruct patient to take lactitol as directed and to take other medications at least 2 hr before or 2 hr after lactitol.
  • Advise patient to stop lactitol and notify health care professional if persistent loose stools occur.
  • Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Evaluation/Desired Outcomes

Evaluation/Desired Outcomes

Increased complete, spontaneous bowel movements.

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