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Used in the treatment of various solid tumors, lymphomas, and leukemias. Also used in some autoimmune disorders such as rheumatoid arthritis (cyclophosphamide, methotrexate). Often used in combinations to minimize individual toxicities and ↑ response. Chemotherapy may be combined with other treatment modalities such as surgery and radiation therapy. Dosages vary greatly, depending on extent of disease, other agents used, and patient's condition. Some agents (doxorubicin, irinotecan) are available in lipid-based formulations that have less toxicity with greater efficacy.