* CAPITALS indicate life-threatening. Underline indicate most frequent.
P-glycoprotein inhibitors, including cyclosporine , may ↑ levels.
May cause fluctuations in INR when used with warfarin ; closely monitor INR.
PO (Adults and Children ≥12 yr): 200 mg 3 times daily for 3 days.
PO (Adults): 550 mg twice daily.
IBS with Diarrhea
PO (Adults): 550 mg 3 times daily for 14 days; if recurrence of symptoms, may treat up to an additional 2 times.
Tablets: 200 mg, 550 mg
Traveler's Diarrhea: Assess frequency and consistency of stools and bowel sounds prior to and during therapy.
Assess fluid and electrolyte balance and skin turgor for dehydration.
Hepatic Encephalopathy: Assess mental status periodically during therapy.
IBS with Diarrhea: Assess frequency and consistency of stools and other IBS symptoms (bloating, cramping) daily.
Monitor bowel function. Diarrhea, abdominal cramping, fever, and bloody stools should be reported to health care professional promptly as a sign of Clostridioides difficile-associated diarrhea (CDAD). May begin up to several wk following cessation of therapy.
Lab Test Considerations:
May cause lymphocytosis, monocytosis, and neutropenia.
Instruct patient to take rifaximin as directed and to complete therapy, even if feeling better. Caution patient to stop taking rifaximin if diarrhea symptoms get worse, persist more than 24–48 hr, or are accompanied by fever or blood in the stool. Consult health care professional if these occur. Advise patient not to treat diarrhea without consulting health care professional. May occur up to several wk after discontinuation of medication.
May cause dizziness. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.
Advise female patients to notify health care professional if pregnant or if pregnancy is suspected, or if breast feeding.
Decreased severity of travelers' diarrhea.
Reduction in risk of overt hepatic encephalopathy recurrence.
Reduction in symptoms of IBS with diarrhea.
rifAXIMin is a sample topic from the Davis's Drug Guide.
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