Notices and Disclaimers
Copyright © 2019 by F. A. Davis Company. All rights reserved.
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Inspiration springs from Passion. . . . Passion is born from unconstrained love, commitment, and a vision no one else can own.
Lynda— my best friend and an extraordinarily gifted nurse— thank you, I could not have done this without your love, strong support, and belief in me. My gratitude to Mom, Dad, Adele, Gram . . . all my family and friends, for I am truly blessed by your humor and faith. A huge hug for my daughters, Sarah and Margaret—I love you very much. To my puppies, Maggie, Taylor, and Emma, for their endless and unconditional love. Many thanks to my friend and wonderful coauthor Mickey; to all the folks at F.A. Davis, especially Rob and Julia for their guidance, support, and great ideas. And, very special thanks to Lisa Houck, publisher, for her friendship, excellent direction, and unwavering encouragement.
Anne M. Van Leeuwen, MA, BS, MT (ASCP)
Medical Laboratory Scientist & Independent Author
An eternity of searching would never have provided me with a man more loving and supportive than my husband, Eric. He is the sunshine in my soul, and I will be forever grateful for the blessing of his presence in my life. I am grateful to my five children, Eric, Anni, Phillip, Mari, and Melissa, for the privilege of being their mom; always remember that you are limited only by your imagination and willingness to try. To my darling grandchildren, watching you grow up always reminds me of the joy of discovery. Life is a gift and the trick is not to focus on its troubles but to enjoy the ride, remember to dance in the rain. To Anne, a forever friend who saw in me the potential to spread my wings, thanks for your patience and guidance, and thanks to Lynda for the miracle of finding me. Thanks to those at F. A. Davis for your kind support. Lastly, to my late beloved parents, thanks with hugs and kisses.
Mickey L. Bladh, RN, MSN
Nurse Educator & Author
Hacienda Heights California
We are so grateful to all the people who have helped us make this book possible. We thank our readers for allowing us this important opportunity to touch their lives. Our goal has always been to assist each individual to find a way to blend emotional and intellectual intelligence into a competent and compassionate approach to patient care. We are also thankful for our association with the F.A. Davis Company. We value and appreciate the efforts of all the people associated with F.A. Davis because without their hard work this publication could not succeed. We recognize all the wonderful people in leadership, the editors, freelance consultants, designers, IT gurus, and digital applications developers, as well as those in sales & marketing, distribution, and finance. We have a deep appreciation for the Davis Educational Consultants. They are tasked with being our voice. Their exceptional ability to communicate is what Davis’s Comprehensive Manual Laboratory and Diagnostic Tests actually brings our book to the market. We would like to give special acknowledgment to the outstanding publishing professionals who were our core support team throughout the development of this edition:
Lisa Houck, Publisher
Robert Allen, Manager, Content Architecture
Julia Curcio, Senior Content Project Manager
Cynthia Naughton, Production Manager, Digital Content
Sandra Glennie, Project Manager, DavisPlus
Carolyn O’Brien, Art & Design Manager
Jaclyn White, Senior Marketing Manager
Bob Butler, Production Manager
Nell Britton MSN, RN, CNE
Trident Technical College Nursing Division
Charleston South Carolina
Cheryl Cassis MSN, RN
Professor of Nursing
Belmont Technical College
St. Clairsville Ohio
Pamela Ellis RN, MSHCA, MSN
Mohave Community College
Bullhead City Arizona
Stephanie Franks MSN, RN
Professor of Nursing
St. Louis Community College–Meramec
St. Louis Missouri
Linda Lott MSN
AD Nursing Instructor
Itawamba Community College
Martha Olson RN, BSN, MS
Nursing Associate Professor
Iowa Lakes Community College
Barbara Thompson RN, BScN, MScN
Professor of Nursing
Sault Ste. Marie Ontario
Edward C. Walton MS, APN-C, NP-C
Assistant Professor of Nursing
Richard Stockton College of New Jersey
Galloway New Jersey
Jean Ann Wilson RN, BSN
Coordinator Norton Annex
Colby Community College
Laboratory and diagnostic testing. The words themselves often conjure up cold and impersonal images of needles, specimens lined up in collection containers, and high- tech electronic equipment. But they do not stand alone. They are tied to, bound with, and tell of health or disease in the blood and tissue of a person. Laboratory and diagnostic studies augment the health- care provider’s assessment of the quality of an individual’s physical being. Test results guide the plans and interventions geared toward strengthening life’s quality and endurance. Beyond the pounding noise of the MRI, the cold steel of the x- ray table, the sting of the needle, the invasive collection of fluids and tissue, and the probing and inspection is the gathering of evidence that supports the healthcare provider’s ability to discern the course of a disease and the progression of its treatment. Laboratory and diagnostic data must be viewed with thought and compassion, however, as well as with microscopes and machines. We must remember that behind the specimen and test result is the person from whom it came, a person who is someone’s son, daughter, mother, father, husband, wife, or friend.
This book is written to help health- care providers in their understanding and interpretation of laboratory and diagnostic procedures and their outcomes. Just as important, it is dedicated to all health- care professionals who experience the wonders in the science of laboratory and diagnostic testing, performed and interpreted in a caring and efficient manner.
The authors continue to enhance and update four main areas in this new edition: organization of the content, pathophysiology that affects test results, patient safety, and patient/family education with expected patient outcomes.
Organization of the content: Time is a precious commodity. The content in the 8th edition has been significantly revised to put the “need to know” information at the top of each study, in the order we imagine readers might prioritize what they need to know. Portability is another important feature of a comprehensive reference book. To that end, repetitive content from the individual studies has been consolidated in the:
The summarized reference tables for critical findings are available in this print edition and online. Also, closely related studies have been combined under a single title to further reduce the size of the book without affecting the number of studies included in the book.
Pathophysiology that affects test results: The Potential Diagnosis section includes explanations of increased or decreased laboratory values to assist in associating pathophysiology with study findings. The authors present a range of age- specific reference normal laboratory values for the neonatal, pediatric, adult, and older adult populations. It should be mentioned that standardized information for the complexity of neonatal, pediatric, and older adult populations is difficult to document. Studies to establish normal ranges for neonates and pediatric patients are limited in number— it is understandable that parents would be reluctant to have their children participate in such studies, especially those involving blood tests. Neonates and pediatric patients are not “little adults,” as so often has been said. Their organ systems are not fully developed and continue to mature over time, which can change the definition of a “normal” finding, incrementally, over time. Evaluating laboratory findings in older adults is also a challenging task. Older adults often have complex health situations. Laboratory values may be increased or decreased in older adults due to the sole or combined effects of malnutrition, alcohol use, medications, and the presence of multiple chronic or acute diseases with or without muted symptoms.
Patient safety: The authors appreciate that nurses are the strongest patient advocates with a huge responsibility to protect the safety of their patients, and we have observed student nurses in clinical settings being interviewed by facility accreditation inspectors, so we have updated reminders for a variety of safety topics. Examples include information related to positive patient identification; hand- off communication of critical information; proper timing of diagnostic procedures; rescheduling of specimen collection for therapeutic drug monitoring; use of evidence- based practices for prevention of surgical site infections; descriptions of study related complications and how to avoid them; the nurse’s role in the process of obtaining an informed written patient consent before providing care, treatment, or services; information regarding the move to track or limit exposure to radiation from imaging studies for adults; and the Image Gently campaign for pediatric patients who undergo diagnostic studies that utilize radiation.
Patient/family education with expected patient outcomes: The fourth area of emphasis coaches the nurse in providing patient education and provides examples for the nurse to anticipate and respond to a patient’s questions or concerns. Elements of this area include describing the purpose of the procedure, study- specific patient preparation, addressing concerns about pain, understanding potential nursing problems in conjunction with the implications of the test results, and potential treatment considerations with related patient/family education, describing postprocedural care and expected patient outcomes. Related Web sites for patient education are included throughout the book to provide additional educational resources for the patient and the nurse.
Laboratory and diagnostic studies are essential components of a complete patient assessment. Examined in conjunction with an individual’s history and physical examination, laboratory studies and diagnostic data provide clues about health status. Nurses are increasingly expected to integrate an understanding of laboratory and diagnostic procedures and expected outcomes in assessment, planning, implementation, and evaluation of nursing care. The data help develop and support nursing diagnoses, interventions, and outcomes.
Nurses may interface with laboratory and diagnostic testing on several levels, including:
Whether the nurse’s role at each level is direct or indirect, the underlying responsibility to the patient, family, and community remains the same.
The authors hope that the changes and additions made to the book will reward users with an expanded understanding of and appreciation for the place laboratory and diagnostic testing holds in the provision of high- quality nursing care and will make it easy for instructors to integrate this important content in their curricula. The authors would like to thank all the users of the previous editions for helping us identify what they like about this book as well as what might improve its value to them. We want to continue this dialogue. As writers, it is our desire to capture the interest of our readers, to provide essential information, and to continue to improve the presentation of the material in the book and ancillary products. We encourage our readers to provide feedback to the Davis Web site and to the publisher’s sales professionals. Your feedback helps us modify the material— to change with your changing needs.
Davis’s Comprehensive Manual of Laboratory and Diagnostic Tests with Nursing Implications, 8th Edition (the "Content") is a publication of 2019 by F. A. Davis Company ("PUBLISHER"), and copyright © 2019 by F. A. Davis Company.
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