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α1-antitrypsin: A1AT, α1-AT, AAT; α1-antitrypsin phenotyping: A1AT phenotype, α1-AT phenotype, AAT phenotype, Pi phenotype.
To assist in the identification of chronic obstructive pulmonary disease (COPD) and liver disease associated with α1-antitrypsin (α1-AT) deficiency.
There are no food, fluid, or activity restrictions unless by medical direction. Oral contraceptives should be withheld 24 hr before the specimen is collected, although this restriction should first be confirmed with the health-care provider (HCP) ordering the test.
Method: Rate nephelometry for α1-AT, isoelectric focusing/high-resolution electrophoresis for α1-AT phenotyping.
|Age||Conventional Units||SI Units (Conventional Units × 0.01)|
|Newborn||124–348 mg/dL||1.24–3.48 g/L|
|Child||110–279 mg/dL||1.1–2.79 g/L|
|Adult||126–226 mg/dL||1.26–2.26 g/L|
There are three major protease inhibitor phenotypes:
The total level of measurable α1-AT varies with genotype. The effects of α1-AT deficiency depend on the patient's personal habits but are most severe in patients who smoke tobacco.
Critical Findings and Potential Interventions