autoantibody

(ot″ō-ant′i-bod″ē )

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[ auto- + antibody ]
ABBR: AAb An antibody, produced by B cells in response to an altered autoantigen on one type of the body's own cells, that attacks and destroys these cells. Autoantibodies are the basis for autoimmune diseases such as rheumatoid arthritis and diabetes mellitus. Several theories exist about why autoantibodies are formed. The most common theory proposes that AAbs develop as the result of a combination of hereditary and environmental risk factors that cause an autoantigen to be falsely recognized as alien by B cells; as a result, antibodies are produced for its destruction.
SEE: antibody; SEE: antigen; SEE: autoimmune disease; SEE: autoimmunity; SEE: immunoglobulin

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