Antidysrhythmic Drugs : Amiodarone, Digoxin, Disopyramide, Flecainide, Lidocaine, Procainamide, Quinidine

Antidysrhythmic Drugs : Amiodarone, Digoxin, Disopyramide, Flecainide, Lidocaine, Procainamide, Quinidine is a topic covered in the Davis's Lab & Diagnostic Tests.

To view the entire topic, please or purchase a subscription.

Nursing Central is the award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Explore these free sample topics:

Nursing Central

-- The first section of this topic is shown below --

General

Synonym/Acronym:
Amiodarone (Cordarone); digoxin (Digitek, Lanoxicaps, and Lanoxin); disopyramide (Norpace, Norpace CR); flecainide (Tambocor); lidocaine (Xylocaine); procainamide(Procanbid, Pronestyl, Pronestyl SR); quinidine (Quinidex Extentabs, Quinidine sulfate SR, Quinidine gluconate SR)

Common Use:
To evaluate specific drugs for subtherapeutic, therapeutic, or toxic levels in treatment of heart failure and cardiac dysrhythmias.

Specimen:
Serum collected in a red-top tube.

DrugRoute of AdministrationRecommended Collection Time
AmiodaroneOralTrough: immediately before next dose
DigoxinOralTrough: 12–24 hr after dose
Never draw peak samples
DisopyramideOralTrough: immediately before next dose
Peak: 2–5 hr after dose
FlecainideOralTrough: immediately before next dose
Peak: 3 hr after dose
Lidocaine Intravenous (IV)15 min; 1 hr; then every 24 hr
ProcainamideIV15 min; 2, 6, 12 hr; then every 24 hr
ProcainamideOralTrough: immediately before next dose
Peak: 75 min after dose
Quinidine sulfateOralTrough: immediately before next dose
Peak: 1 hr after dose
Quinidine gluconateOralTrough: immediately before next dose
Peak: 5 hr after dose
Quinidine polygalacturonateOralTrough: immediately before next dose
Peak: 2 hr after dose

Normal Findings:
(Method: Immunoassay)

Drug (Indication)Therapeutic Range Conventional UnitsConversion to SI UnitsSI UnitsHalf-Life (hr)Volume of Distribution (L/kg)Protein Binding (%)Excretion
Amiodarone0.5–2.5 mcg/mLSI units = Conventional units × 1.550.8–3.9 micromol/L250–120020–10095–971° hepatic
Digoxin0.5–2 ng/mLSI units = Conventional units × 1.280.6–2.6 nmol/L20–60720–301° renal
Disopyramide2.8–7 mcg/mLSI units = Conventional units × 2.958.3–20.6 micromol/L4–100.7–0.920–601° renal
Flecainide0.2–1 mcg/mLSI units = Conventional units × 2.410.5–2.4 micromol/L7–195–1340–501° renal
Lidocaine 1.5–5 mcg/mLSI units = Conventional units × 4.276.4–21.4 micromol/L1.5–21–1.560–801° hepatic
Procainamide4–10 mcg/mLSI units = Conventional units × 4.2517–42 micromol/L2–62–410–201° renal
N-acetyl procainamide10–20 mcg/mLSI units = Conventional units × 4.2542–85 micromol/L81° renal
Quinidine2–5 mcg/mLSI units = Conventional units × 3.086–15 micromol/L6–82–370–90Renal and hepatic

-- To view the remaining sections of this topic, please or purchase a subscription --

Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Antidysrhythmic Drugs : Amiodarone, Digoxin, Disopyramide, Flecainide, Lidocaine, Procainamide, Quinidine ID - 425005 Y1 - 2017 PB - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425005/all/Antidysrhythmic_Drugs_:_Amiodarone__Digoxin__Disopyramide__Flecainide__Lidocaine__Procainamide__Quinidine ER -