Gastrin and Gastrin Stimulation Test


Gastrin and Secretin Stimulation Test

To evaluate gastric production to assist in diagnosis of gastric disease such as Zollinger-Ellison syndrome and gastric cancer.

Patient Preparation
There are no fluid or activity restrictions unless by medical direction. Instruct the patient to fast for 12 hr before the test. Instruct the patient to refrain from the use of chewing gum or tobacco products for at least 4 hr prior to and for the duration of the test. Instruct the patient to withhold caffeine and alcohol for 12 to 24 hr, as ordered by the health-care provider (HCP); proton pump inhibitors and other medications that interfere with GI motility should be discontinued, by medical direction, for at least 2 wk prior to the test. Protocols may vary among facilities.

Normal Findings
Method: Immunoassay.

AgeConventional UnitsSI Units (Conventional Units × 0.481)
ChildLess than 125 pg/mLLess than 60.1 pmol/L
AdultLess than 100 pg/mLLess than 48.1 pmol/L
Values represent fasting levels.
Stimulation Tests
Gastrin stimulation test with secretin; 0.4 mcg/kg by IVNo response or slight increase over baseline; increase of greater than 200 pg/ml (SI units: 96 pmol/L) above baseline is considered abnormal
Calcium may also be used as a stimulant.

Critical Findings and Potential Interventions

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