Analgesic, Anti-inflammatory, and Antipyretic Drugs: Acetaminophen, Acetylsalicylic Acid

Analgesic, Anti-inflammatory, and Antipyretic Drugs: Acetaminophen, Acetylsalicylic Acid is a topic covered in the Davis's Lab & Diagnostic Tests.

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General

Synonym/Acronym:
Acetaminophen (Acephen, Aceta, Apacet, APAP 500, Aspirin Free Anacin, Banesin, Cetaphen, Dapa, Datril, Dorcol, Exocrine, FeverAll, Genapap, Genebs, Halenol, Little Fevers, Liquiprin, Mapap, Myapap, Nortemp, Pain-Eze, Panadol, Paracetamol, Redutemp, Ridenol, Silapap, Tempra, Tylenol, Ty-Pap, Uni-Ace, Valorin); Acetylsalicylic acid (Anacin, ASA, Aspergum, aspirin, Bufferin, Easprin, Ecotrin, Empirin, Measurin, salicylate, Synalgos, ZORprin)

Common Use:
To assist in monitoring therapeutic drug levels and detect toxic levels of acetaminophen and salicylate in suspected overdose. It should be noted that acetaminophen and acetylsalicylic acid are contained in many other medications, such as cold and cough medicines.

Specimen:
Serum collected in a red-top tube.

Normal Findings:
(Method: Immunoassay)

DrugTherapeutic Range Conventional UnitsConversion to SI UnitsSI UnitsHalf-LifeVolume of DistributionProtein BindingExcretion
Acetaminophen5–20 mcg/mLSI units = Conventional units × 6.6233–132 micromol/L1–3 hr0.95 L/kg10%–25% (dose dependent)85%–95% hepatic; metabolites, renal
Salicylate10–30 mg/dL (anti-inflammatory); 2–10 mg/dL (antipyretic/analgesic)SI units = Conventional units × 0.0730.7–2.2 mmol/L (anti-inflammatory); 0.2–0.7 mmol/L (antipyretic/analgesic)2–3 hr0.1–0.3 L/kg90%–95%1° hepatic; metabolites, renal

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Citation

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TY - ELEC T1 - Analgesic, Anti-inflammatory, and Antipyretic Drugs: Acetaminophen, Acetylsalicylic Acid ID - 425039 Y1 - 2017 PB - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425039/all/Analgesic__Anti_inflammatory__and_Antipyretic_Drugs:_Acetaminophen__Acetylsalicylic_Acid ER -