Porphyrins, Urine

Porphyrins, Urine is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
Coproporphyrin, porphobilinogen, urobilinogen, and other porphyrins.

Rationale
To assess for porphyrins in the urine to assist with diagnosis of genetic disorders associated with porphyrin synthesis as well as heavy metal toxicity.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction. Usually, a 24-hr urine collection is ordered. As appropriate, provide the required urine collection container and specimen collection instructions.

Normal Findings
Method: High-performance liquid chromatography for porphyrins; spectrophotometry for Δ-aminolevulinic acid and porphobilinogen.

TestConventional UnitsSI Units
(Conventional units × 1.53)
Coproporphyrin I0–24 mcg/24 h0–36.7 nmol/24 hr
Coproporphyrin III0–74 mcg/24 hr0–113.2 nmol/24 hr
(Conventional units × 1.43)
Uroporphyrins0–24 mcg/24 hr0–34.3 nmol/24 hr
(Conventional units × 1.34)
HexacarboxylporphyrinLess than 10 mcg/24 hrLess than 10.34 nmol/24 hr
(Conventional units × 1.27)
HeptacarboxylporphyrinLess than 4 mcg/24 hrLess than 5.1 nmol/24 hr
(Conventional units × 4.42)
PorphobilinogenLess than 2 mg/24 hrLess than 8.8 micromol/24 hr
(Conventional units × 7.626)
Δ-Aminolevulinic acid1.5–7.5 mg/24 hr11.4–57.2 micromol/24 hr

Critical Findings and Potential Interventions
N/A

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