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Coproporphyrin, porphobilinogen, urobilinogen, and other porphyrins.
To assess for porphyrins in the urine to assist with diagnosis of genetic disorders associated with porphyrin synthesis as well as heavy metal toxicity.
There are no food, fluid, activity, or medication restrictions unless by medical direction. Usually, a 24-hr urine collection is ordered. As appropriate, provide the required urine collection container and specimen collection instructions.
Method: High-performance liquid chromatography for porphyrins; spectrophotometry for Δ-aminolevulinic acid and porphobilinogen.
|Test||Conventional Units||SI Units|
|(Conventional units × 1.53)|
|Coproporphyrin I||0–24 mcg/24 h||0–36.7 nmol/24 hr|
|Coproporphyrin III||0–74 mcg/24 hr||0–113.2 nmol/24 hr|
|(Conventional units × 1.43)|
|Uroporphyrins||0–24 mcg/24 hr||0–34.3 nmol/24 hr|
|(Conventional units × 1.34)|
|Hexacarboxylporphyrin||Less than 10 mcg/24 hr||Less than 10.34 nmol/24 hr|
|(Conventional units × 1.27)|
|Heptacarboxylporphyrin||Less than 4 mcg/24 hr||Less than 5.1 nmol/24 hr|
|(Conventional units × 4.42)|
|Porphobilinogen||Less than 2 mg/24 hr||Less than 8.8 micromol/24 hr|
|(Conventional units × 7.626)|
|Δ-Aminolevulinic acid||1.5–7.5 mg/24 hr||11.4–57.2 micromol/24 hr|
Critical Findings and Potential Interventions