Davis's Lab & Diagnostic Tests
Porphyrins, Blood and Urine
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General
Synonym/Acronym:
Blood: Erythrocyte protoporphyrin, EP, free erythrocyte protoporphyrin, FEP; and Urine: Coproporphyrin, porphobilinogen, urobilinogen, and other porphyrins.
Rationale
To assist in diagnosing acquired and inherited conditions associated with porphyrias, such as anemias related to chronic disease, hemolysis, iron deficiency, and heavy metal toxicity.
Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction. Usually, a 24-hr urine collection is ordered for urine testing. As appropriate, provide the required urine collection container and specimen collection instructions.
Normal Findings
Method: Blood: Fluorometry for erythrocyte protoporphyrin; Urine: High-performance liquid chromatography for porphyrins; spectrophotometry for porphobilinogen.
| Conventional Units | SI Units (Conventional Units × 0.0178) |
|---|---|
| Adult | |
| Male | |
| Less than 30 mcg/dL | Less than 0.534 micromol/L |
| Female | |
| Less than 40 mcg/dL | Less than 0.712 micromol/L |
| Test | Units |
|---|---|
| Coproporphyrins | |
| Male | 0–230 nmol/24 hr |
| Female | 0–170 nmol/24 hr |
| Hexacarboxylporphyrin | 0–8 nmol/24 hr |
| Heptacarboxylporphyrin | 0–9 nmol/24 hr |
| Uroporphyrins | 0–30 nmol/24 hr |
| Porphobilinogen | 0–2 mg/24 hr |
Critical Findings and Potential Interventions
N/A
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General
Synonym/Acronym:
Blood: Erythrocyte protoporphyrin, EP, free erythrocyte protoporphyrin, FEP; and Urine: Coproporphyrin, porphobilinogen, urobilinogen, and other porphyrins.
Rationale
To assist in diagnosing acquired and inherited conditions associated with porphyrias, such as anemias related to chronic disease, hemolysis, iron deficiency, and heavy metal toxicity.
Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction. Usually, a 24-hr urine collection is ordered for urine testing. As appropriate, provide the required urine collection container and specimen collection instructions.
Normal Findings
Method: Blood: Fluorometry for erythrocyte protoporphyrin; Urine: High-performance liquid chromatography for porphyrins; spectrophotometry for porphobilinogen.
| Conventional Units | SI Units (Conventional Units × 0.0178) |
|---|---|
| Adult | |
| Male | |
| Less than 30 mcg/dL | Less than 0.534 micromol/L |
| Female | |
| Less than 40 mcg/dL | Less than 0.712 micromol/L |
| Test | Units |
|---|---|
| Coproporphyrins | |
| Male | 0–230 nmol/24 hr |
| Female | 0–170 nmol/24 hr |
| Hexacarboxylporphyrin | 0–8 nmol/24 hr |
| Heptacarboxylporphyrin | 0–9 nmol/24 hr |
| Uroporphyrins | 0–30 nmol/24 hr |
| Porphobilinogen | 0–2 mg/24 hr |
Critical Findings and Potential Interventions
N/A
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