Davis's Lab & Diagnostic Tests
Porphyrins, Urine
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Synonym/Acronym:
Coproporphyrin, porphobilinogen, urobilinogen, and other porphyrins.
Rationale
To assess for porphyrins in the urine to assist with diagnosis of genetic disorders associated with porphyrin synthesis as well as heavy metal toxicity.
Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction. Usually, a 24-hr urine collection is ordered. As appropriate, provide the required urine collection container and specimen collection instructions.
Normal Findings
Method: High-performance liquid chromatography for porphyrins; spectrophotometry for Δ-aminolevulinic acid and porphobilinogen.
| Test | Conventional Units | SI Units |
|---|---|---|
| (Conventional units × 1.53) | ||
| Coproporphyrin I | 0–24 mcg/24 h | 0–36.7 nmol/24 hr |
| Coproporphyrin III | 0–74 mcg/24 hr | 0–113.2 nmol/24 hr |
| (Conventional units × 1.43) | ||
| Uroporphyrins | 0–24 mcg/24 hr | 0–34.3 nmol/24 hr |
| (Conventional units × 1.34) | ||
| Hexacarboxylporphyrin | Less than 10 mcg/24 hr | Less than 10.34 nmol/24 hr |
| (Conventional units × 1.27) | ||
| Heptacarboxylporphyrin | Less than 4 mcg/24 hr | Less than 5.1 nmol/24 hr |
| (Conventional units × 4.42) | ||
| Porphobilinogen | Less than 2 mg/24 hr | Less than 8.8 micromol/24 hr |
| (Conventional units × 7.626) | ||
| Δ-Aminolevulinic acid | 1.5–7.5 mg/24 hr | 11.4–57.2 micromol/24 hr |
Critical Findings and Potential Interventions
N/A
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Synonym/Acronym:
Coproporphyrin, porphobilinogen, urobilinogen, and other porphyrins.
Rationale
To assess for porphyrins in the urine to assist with diagnosis of genetic disorders associated with porphyrin synthesis as well as heavy metal toxicity.
Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction. Usually, a 24-hr urine collection is ordered. As appropriate, provide the required urine collection container and specimen collection instructions.
Normal Findings
Method: High-performance liquid chromatography for porphyrins; spectrophotometry for Δ-aminolevulinic acid and porphobilinogen.
| Test | Conventional Units | SI Units |
|---|---|---|
| (Conventional units × 1.53) | ||
| Coproporphyrin I | 0–24 mcg/24 h | 0–36.7 nmol/24 hr |
| Coproporphyrin III | 0–74 mcg/24 hr | 0–113.2 nmol/24 hr |
| (Conventional units × 1.43) | ||
| Uroporphyrins | 0–24 mcg/24 hr | 0–34.3 nmol/24 hr |
| (Conventional units × 1.34) | ||
| Hexacarboxylporphyrin | Less than 10 mcg/24 hr | Less than 10.34 nmol/24 hr |
| (Conventional units × 1.27) | ||
| Heptacarboxylporphyrin | Less than 4 mcg/24 hr | Less than 5.1 nmol/24 hr |
| (Conventional units × 4.42) | ||
| Porphobilinogen | Less than 2 mg/24 hr | Less than 8.8 micromol/24 hr |
| (Conventional units × 7.626) | ||
| Δ-Aminolevulinic acid | 1.5–7.5 mg/24 hr | 11.4–57.2 micromol/24 hr |
Critical Findings and Potential Interventions
N/A
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