Antimicrobial Drugs—Aminoglycosides: Amikacin, Gentamicin, Tobramycin; Tricyclic Glycopeptide: Vancomycin

Antimicrobial Drugs—Aminoglycosides: Amikacin, Gentamicin, Tobramycin; Tricyclic Glycopeptide: Vancomycin is a topic covered in the Davis's Lab & Diagnostic Tests.

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General

Synonym/Acronym:
Amikacin (generic only); gentamicin (Garamycin, Genoptic, Gentacidin, Gentafair, Gentak, Gentamar, Gentrasul, G-myticin, Oco-Mycin, Spectro-Genta); tobramycin (Nebcin, Tobrex); vancomycin (Lyphocin, Vancocin, Vancoled)

Common Use:
To evaluate specific drugs for subtherapeutic, therapeutic, or toxic levels in treatment of infection.

Specimen:
Serum collected in a red-top tube.

DrugRoute of AdministrationRecommended Collection Time*
AmikacinIV, IMTrough: immediately before next dose
Peak: 30 min after the end of a 30-min IV infusion
GentamicinIV, IMTrough: immediately before next dose
Peak: 30 min after the end of a 30-min IV infusion
TobramycinIV, IMTrough: immediately before next dose
Peak: 30 min after the end of a 30-min IV infusion
Tricyclic glycopeptide and vancomycinIV, POTrough: immediately before next dose Peak: 30–60 min after the end of a 60-min IV infusion
*Usually after fifth dose if given every 8 hr or third dose if given every 12 hr.IM = intramuscular; IV = intravenous; PO = by mouth.

Normal Findings:
(Method: Immunoassay)

DrugTherapeutic Range Conventional UnitsConversion to SI UnitsSI UnitsHalf-Life (hr)Distribution (L/kg)Volume of Binding (%)Excretion
Amikacin
Peak15–30 mcg/mLSI units = Conventional units × 1.7126–51 micromol/L4–80.4–1.3501° renal
Trough4–8 mcg/mLSI units = Conventional units × 1.717–14 micromol/L1° renal
Gentamicin (Standard dosing)
Peak5–10 mcg/mLSI units = Conventional units × 2.0910–21 micromol/L4–80.4–1.3501° renal
TroughLess than 2 mcg/mLSI units = Conventional units × 2.09Less than 4 micromol/L1° renal
Tobramycin (Standard dosing)
Peak4–8 mcg/mLSI units = Conventional units × 2.098.4–16 micromol/L4–80.4–1.3501° renal
TroughLess than 1 mcg/mLSI units = Conventional units × 2.09Less than 2.1 micromol/L1° renal
Tobramycin (Once daily dosing)
Peak8–12 mcg/mLSI units = Conventional units × 2.0916.7–25 micromol/L4–80.4–1.3501° renal
TroughLess than 0.5 mcg/mLSI units = Conventional units × 2.09Less than 1 micromol/L1° renal
Vancomycin
Trough (general) values vary with indication5–15 mcg/mLSI units = Conventional units × 0.693–10 micromol/L6–120.4–110–151° renal

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Citation

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TY - ELEC T1 - Antimicrobial Drugs—Aminoglycosides: Amikacin, Gentamicin, Tobramycin; Tricyclic Glycopeptide: Vancomycin ID - 425064 Y1 - 2017 PB - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425064/all/Antimicrobial_Drugs—Aminoglycosides:_Amikacin__Gentamicin__Tobramycin ER -