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Creatine Kinase and Isoenzymes

Creatine Kinase and Isoenzymes is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
CK and isoenzymes.

Rationale
To monitor MI and some disorders of the musculoskeletal system, such as Duchenne muscular dystrophy.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Enzymatic for CK, electrophoresis for isoenzymes; enzyme immunoassay techniques are in common use for CK-MB.

Conventional and SI Units
Total CK
 Newborn–1 yrUp to 2 × adult values
 Male (children and adults)50–204 units/L
 Female (children and adults)36–160 units/L
CK Isoenzymes by Electrophoresis
 CK-BBAbsent
 CK-MB0–4%
 CK-MM96–100%
CK-MB by Immunoassay0–5 ng/mL
CK-MB Index0–2.5
CK = creatine kinase; CK-BB = CK isoenzyme in brain; CK-MB = CK isoenzyme in heart; CK‑MM = CK isoenzyme in skeletal muscle.The CK-MB index is the CK-MB (by immunoassay) divided by the total CK and then multiplied by 100. For example, a CK-MB by immunoassay of 25 ng/mL with a total CK of 250 units/L would have a CK-MB index of 10.Elevations in total CK occur after exercise. Values in older adults may decline slightly related to loss of muscle mass.

Critical Findings and Potential Interventions
N/A

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Creatine Kinase and Isoenzymes." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425081/all/Creatine_Kinase_and_Isoenzymes.
Bladh ML, Van Leeuwen AM. Creatine Kinase and Isoenzymes. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425081/all/Creatine_Kinase_and_Isoenzymes. Accessed August 21, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Creatine Kinase and Isoenzymes. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425081/all/Creatine_Kinase_and_Isoenzymes
Bladh ML, Van Leeuwen AM. Creatine Kinase and Isoenzymes [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 August 21]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425081/all/Creatine_Kinase_and_Isoenzymes.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Creatine Kinase and Isoenzymes ID - 425081 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425081/all/Creatine_Kinase_and_Isoenzymes PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -