Insulin and Insulin Response to Glucose
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To assess the amount of insulin secreted in response to blood glucose to assist in diagnosis of types of hypoglycemia and insulin-resistant pathologies.
There are no fluid or activity restrictions unless by medical direction. If a single sample is to be collected, the patient should have fasted and refrained, with medical direction, from taking insulin or other oral hypoglycemic drugs for at least 8 hr before specimen collection. If serial specimens are to be collected, the patient should be prepared as for a standard oral glucose tolerance test over a 5-hr period. Protocols may vary among facilities.
|75-g Glucose Load||Insulin||SI Units (Conventional Units × 6.945)||Tolerance for Glucose (Hypoglycemia)|
|Fasting||Less than 17 micro-international units/L||Less than 118.1 pmol/L||Less than 110 mg/dL|
|30 min||6–86 micro-international units/L||41.7–597.3 pmol/L||Less than 200 mg/dL|
|1 hr||8–118 micro-international units/L||55.6–819.5 pmol/L||Less than 200 mg/dL|
|2 hr||5–55 micro-international units/L||34.7–382 pmol/L||Less than 140 mg/dL|
|3 hr||Less than 25 micro-international units/L||Less than 174 pmol/L||65–120 mg/dL|
|4 hr||Less than 15 micro-international units/L||Less than 104.2 pmol/L||65–120 mg/dL|
|5 hr||Less than 8 micro-international units/L||Less than 55.6 pmol/L||65–115 mg/dL|
Critical Findings and Potential Interventions