Davis's Lab & Diagnostic Tests
Insulin and Insulin Response to Glucose
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Synonym/Acronym:
N/A
Rationale
To assess the amount of insulin secreted in response to blood glucose to assist in diagnosis of types of hypoglycemia and insulin-resistant pathologies.
Patient Preparation
There are no fluid or activity restrictions unless by medical direction. If a single sample is to be collected, the patient should have fasted and refrained, with medical direction, from taking insulin or other oral hypoglycemic drugs for at least 8 hr before specimen collection. If serial specimens are to be collected, the patient should be prepared as for a standard oral glucose tolerance test over a 5-hr period. Protocols may vary among facilities.
Normal Findings
Method: Immunoassay.
| 75-g Glucose Load | Insulin | SI Units (Conventional Units × 6.945) | Tolerance for Glucose (Hypoglycemia) |
|---|---|---|---|
| Fasting | Less than 17 micro-international units/L | Less than 118.1 pmol/L | Less than 110 mg/dL |
| 30 min | 6–86 micro-international units/L | 41.7–597.3 pmol/L | Less than 200 mg/dL |
| 1 hr | 8–118 micro-international units/L | 55.6–819.5 pmol/L | Less than 200 mg/dL |
| 2 hr | 5–55 micro-international units/L | 34.7–382 pmol/L | Less than 140 mg/dL |
| 3 hr | Less than 25 micro-international units/L | Less than 174 pmol/L | 65–120 mg/dL |
| 4 hr | Less than 15 micro-international units/L | Less than 104.2 pmol/L | 65–120 mg/dL |
| 5 hr | Less than 8 micro-international units/L | Less than 55.6 pmol/L | 65–115 mg/dL |
Critical Findings and Potential Interventions
N/A
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Synonym/Acronym:
N/A
Rationale
To assess the amount of insulin secreted in response to blood glucose to assist in diagnosis of types of hypoglycemia and insulin-resistant pathologies.
Patient Preparation
There are no fluid or activity restrictions unless by medical direction. If a single sample is to be collected, the patient should have fasted and refrained, with medical direction, from taking insulin or other oral hypoglycemic drugs for at least 8 hr before specimen collection. If serial specimens are to be collected, the patient should be prepared as for a standard oral glucose tolerance test over a 5-hr period. Protocols may vary among facilities.
Normal Findings
Method: Immunoassay.
| 75-g Glucose Load | Insulin | SI Units (Conventional Units × 6.945) | Tolerance for Glucose (Hypoglycemia) |
|---|---|---|---|
| Fasting | Less than 17 micro-international units/L | Less than 118.1 pmol/L | Less than 110 mg/dL |
| 30 min | 6–86 micro-international units/L | 41.7–597.3 pmol/L | Less than 200 mg/dL |
| 1 hr | 8–118 micro-international units/L | 55.6–819.5 pmol/L | Less than 200 mg/dL |
| 2 hr | 5–55 micro-international units/L | 34.7–382 pmol/L | Less than 140 mg/dL |
| 3 hr | Less than 25 micro-international units/L | Less than 174 pmol/L | 65–120 mg/dL |
| 4 hr | Less than 15 micro-international units/L | Less than 104.2 pmol/L | 65–120 mg/dL |
| 5 hr | Less than 8 micro-international units/L | Less than 55.6 pmol/L | 65–115 mg/dL |
Critical Findings and Potential Interventions
N/A
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