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Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium

Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium is a topic covered in the Davis's Lab & Diagnostic Tests.

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General

Synonym/Acronym:
Antipsychotic drugs: haloperidol (Dozic, Fortunan, Haldol, Haldol Decanoate, Haloneural, Serenace); antimanic drugs: lithium (Cibalith-S, Eskalith, Lithane, Lithobid, Lithonate, Lithotabs, PFI-Lith, Phasal)

Common Use:
To assist in monitoring subtherapuetic, therapeutic, or toxic drug levels related to medical interventions.

Specimen:
Serum collected in a red-top tube.

DrugRoute of AdministrationRecommended Collection Time
HaloperidolOralPeak: 3–6 hr
LithiumOralTrough: at least 12 hr after last dose; steady state occurs at 90–120 hr

Normal Findings:
(Method: Chromatography for haloperidol; ion-selective electrode for lithium)

DrugTherapeutic Range Conventional UnitsConversion to SI UnitsTherapeutic Range SI UnitsHalf-Life (hr)Volume of Distribution (L/kg)Protein Binding (%)Excretion
Haloperidol6–24 ng/mLSI units = Conventional units x 2.6616–64 nmol/L15–4018–3090Hepatic
Lithium (chronic)0.6–1.2 mEq/LSI units = Conventional units x 10.6–1.2 mmol/L18–240.7–10Renal

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425155/all/Antipsychotic_Drugs_and_Antimanic_Drugs:_Haloperidol__Lithium.
Bladh ML, Van Leeuwen AM. Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425155/all/Antipsychotic_Drugs_and_Antimanic_Drugs:_Haloperidol__Lithium. Accessed March 23, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425155/all/Antipsychotic_Drugs_and_Antimanic_Drugs:_Haloperidol__Lithium
Bladh ML, Van Leeuwen AM. Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 March 23]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425155/all/Antipsychotic_Drugs_and_Antimanic_Drugs:_Haloperidol__Lithium.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium ID - 425155 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425155/all/Antipsychotic_Drugs_and_Antimanic_Drugs:_Haloperidol__Lithium PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -