Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium
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Antipsychotic drugs: haloperidol (Dozic, Fortunan, Haldol, Haldol Decanoate, Haloneural, Serenace); antimanic drugs: lithium (Cibalith-S, Eskalith, Lithane, Lithobid, Lithonate, Lithotabs, PFI-Lith, Phasal)
To assist in monitoring subtherapuetic, therapeutic, or toxic drug levels related to medical interventions.
Serum collected in a red-top tube.
|Drug||Route of Administration||Recommended Collection Time|
|Haloperidol||Oral||Peak: 3–6 hr|
|Lithium||Oral||Trough: at least 12 hr after last dose; steady state occurs at 90–120 hr|
(Method: Chromatography for haloperidol; ion-selective electrode for lithium)
|Drug||Therapeutic Range Conventional Units||Conversion to SI Units||Therapeutic Range SI Units||Half-Life (hr)||Volume of Distribution (L/kg)||Protein Binding (%)||Excretion|
|Haloperidol||6–24 ng/mL||SI units = Conventional units x 2.66||16–64 nmol/L||15–40||18–30||90||Hepatic|
|Lithium (chronic)||0.6–1.2 mEq/L||SI units = Conventional units x 1||0.6–1.2 mmol/L||18–24||0.7–1||0||Renal|