Protein, Blood, Total and Fractions

Protein, Blood, Total and Fractions is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
TP, SPEP (fractions include albumin, α1-globulin, α2-globulin, β-globulin, and γ-globulin).

Rationale
To assess nutritional status related to various disease and conditions such as dehydration, burns, and malabsorption.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Spectrophotometry for total protein, electrophoresis for protein fractions.


Total Protein
AgeConventional UnitsSI Units (Conventional Units × 10)
Newborn–5 days3.8–6.2 g/dL38–62 g/L
1–3 yr5.9–7 g/dL59–70 g/L
4–6 yr5.9–7.8 g/dL59–78 g/L
7–9 yr6.2–8.1 g/dL62–81 g/L
10–19 yr6.3–8.6 g/dL63–86 g/L
Adult6–8 g/dL60–80 g/L
Values may be slightly decreased in older adults due to insufficient intake or the effects of medications and the presence of multiple chronic or acute diseases with or without muted symptoms.

Protein Fractions
Conventional UnitsSI Units (Conventional Units × 10)
Albumin3.4–4.8 g/dL34–48 g/L
α1-Globulin0.2–0.4 g/dL2–4 g/L
α2-Globulin0.4–0.8 g/dL4–8 g/L
β-Globulin0.5–1 g/dL5–10 g/L
.-Globulin0.6–1.2 g/dL6–12 g/L
Values may be slightly decreased in older adults due to insufficient intake or the effects of medications and the presence of multiple chronic or acute diseases with or without muted symptoms.

Critical Findings and Potential Interventions
N/A

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