Alkaline Phosphatase and Isoenzymes

Alkaline Phosphatase and Isoenzymes is a topic covered in the Davis's Lab & Diagnostic Tests.

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Alk Phos, ALP and fractionation, heat-stable ALP.

To assist in the diagnosis of liver and bone disease.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Spectrophotometry for total alkaline phosphatase, inhibition/electrophoresis for fractionation.

Age/GenderTotal ALP Conventional and SI UnitsBone Fraction Conventional and SI UnitsLiver Fraction Conventional and SI Units
 Male75–375 units/LNANA
 Female65–350 units/LNANA
1–8 yr
 Male70–364 units/L50–319 units/LLess than 8–76 units/L
 Female73–378 units/L56–300 units/LLess than 8–53 units/L
9–12 yr
 Male112–476 units/L78–339 units/LLess than 8–81 units/L
 Female98–448 units/L78–353 units/LLess than 8–62 units/L
13–14 yr
 Male112–476 units/L78–389 units/LLess than 8–48 units/L
 Female56–350 units/L28–252 units/LLess than 8–50 units/L
15 yr
 Male70–378 units/L48–311 units/LLess than 8–39 units/L
 Female42–168 units/L20–115 units/LLess than 8–53 units/L
16 yr
 Male70–378 units/L48–311 units/LLess than 8–39 units/L
 Female28–126 units/L14–87 units/LLess than 8–50 units/L
17 yr
 Male56–238 units/L34–190 units/LLess than 8–39 units/L
 Female28–126 units/L17–84 units/LLess than 8–53 units/L
 Male35–142 units/L11–73 units/L0–93 units/L
 Female25–125 units/L11–73 units/L0–93 units/L
ALP levels vary by age and gender; values in children are higher than in adults because of the level of bone growth and development. Values may be slightly elevated in older adults.

Critical Findings and Potential Interventions

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