Alkaline Phosphatase and Isoenzymes

Alkaline Phosphatase and Isoenzymes is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
Alk Phos, ALP and fractionation, heat-stable ALP.

Rationale
To assist in the diagnosis of liver and bone disease.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Spectrophotometry for total alkaline phosphatase, inhibition/electrophoresis for fractionation.

Age/GenderTotal ALP Conventional and SI UnitsBone Fraction Conventional and SI UnitsLiver Fraction Conventional and SI Units
Newborn
 Male75–375 units/LNANA
 Female65–350 units/LNANA
1–8 yr
 Male70–364 units/L50–319 units/LLess than 8–76 units/L
 Female73–378 units/L56–300 units/LLess than 8–53 units/L
9–12 yr
 Male112–476 units/L78–339 units/LLess than 8–81 units/L
 Female98–448 units/L78–353 units/LLess than 8–62 units/L
13–14 yr
 Male112–476 units/L78–389 units/LLess than 8–48 units/L
 Female56–350 units/L28–252 units/LLess than 8–50 units/L
15 yr
 Male70–378 units/L48–311 units/LLess than 8–39 units/L
 Female42–168 units/L20–115 units/LLess than 8–53 units/L
16 yr
 Male70–378 units/L48–311 units/LLess than 8–39 units/L
 Female28–126 units/L14–87 units/LLess than 8–50 units/L
17 yr
 Male56–238 units/L34–190 units/LLess than 8–39 units/L
 Female28–126 units/L17–84 units/LLess than 8–53 units/L
Adult
 Male35–142 units/L11–73 units/L0–93 units/L
 Female25–125 units/L11–73 units/L0–93 units/L
ALP levels vary by age and gender; values in children are higher than in adults because of the level of bone growth and development. Values may be slightly elevated in older adults.

Critical Findings and Potential Interventions
N/A

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