Type your tag names separated by a space and hit enter

Hexosaminidase A and B

Hexosaminidase A and B is a topic covered in the Davis's Lab & Diagnostic Tests.

To view the entire topic, please or purchase a subscription.

Nursing Central is the award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Explore these free sample topics:

Nursing Central

-- The first section of this topic is shown below --

General

Synonym/Acronym:
TSD (Tay-Sachs disease) testing.

Common Use:
To assist in diagnosing Tay-Sachs disease by identifying a hexosaminidase enzyme deficiency.

Specimen:
Serum collected in a yellow-top (acid-citrate-dextrose [ACD]) or a red-top tube for hexosaminidase enzyme assay; lavender-top (EDTA), pink-top (K2 EDTA) or yellow-top tube (ACD) for molecular polymerase chain reaction (PCR) assay.

Normal Findings:
(Method: Fluorometry for enzyme assay, PCR/primer extension for molecular assay)


Enzyme Assay
Total HexosaminidaseConventional UnitsSI Units (Conventional Units × 0.0167)
Noncarrier589–955 nmol/hr/mL9.83–15.95 units/L
Heterozygote465–675 nmol/hr/mL7.77–11.27 units/L
Tay-Sachs homozygoteGreater than 1,027 nmol/hr/mLGreater than 17.15 units/L
Hexosaminidase AConventional UnitsSI Units (Conventional Units × 0.0167)
Noncarrier456–592 nmol/hr/mL or 55–76% of total hexosaminidase7.62–9.88 units/L or 55–76% of total hexosaminidase
Heterozygote197–323 nmol/hr/mL3.29–5.39 units/L
Tay-Sachs homozygote0 nmol/hr/mL0 units/L
Hexosaminidase BConventional UnitsSI Units (Conventional Units × 0.0167)
Noncarrier12–32 nmol/hr/mL0.2–0.54 units/L
Heterozygote21–81 nmol/hr/mL0.35–1.35 units/L
Tay-Sachs homozygoteGreater than 305 nmol/hr/mLGreater than 5.09 units/L

Molecular assay: Negative for HEXA 7 mutations (samples are evaluated for seven specific HEXA gene mutations).

-- To view the remaining sections of this topic, please or purchase a subscription --

Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Hexosaminidase a and B." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425267/all/Hexosaminidase_A_and_B.
Bladh ML, Van Leeuwen AM. Hexosaminidase A and B. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425267/all/Hexosaminidase_A_and_B. Accessed March 25, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Hexosaminidase A and B. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425267/all/Hexosaminidase_A_and_B
Bladh ML, Van Leeuwen AM. Hexosaminidase a and B [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 March 25]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425267/all/Hexosaminidase_A_and_B.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Hexosaminidase A and B ID - 425267 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425267/all/Hexosaminidase_A_and_B PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -