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α1-Fetoprotein is a topic covered in the Davis's Lab & Diagnostic Tests.

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Common Use:
To assist in the evaluation of fetal health related to neural tube defects and some forms of liver cancer.

Serum collected in a gold-, red-, or red/gray-top tube. For maternal triple- or quad-marker testing, include human chorionic gonadotropin and free estriol measurement.

Normal Findings:
(Method: Immunochemiluminometric assay)

α1-Fetoprotein as a Tumor Marker: Males, Females, and Children

Males (Conventional Units)SI Units (Conventional Units × 1)Females (Conventional Units)SI Units (Conventional Units × 1)
Less than 1 mo0.5–16,387 ng/mL0.5–16,387 mcg/L0.5–18,964 ng/mL0.5–18,964 mcg/L
1–11 mo0.5–28.3 ng/mL0.5–28.3 mcg/L0.5–77 ng/mL0.5–77 mcg/L
1–3 yr0.5–7.9 ng/mL0.5–7.9 mcg/L0.5–11.1 ng/mL0.5–11.1 mcg/L
4 yr and olderLess than 6.1 ng/mLLess than 6.1 mcg/LLess than 6.1 ng/mLLess than 6.1 mcg/L
Values may be higher for premature newborns.
α1-Fetoprotein (AFP) in Maternal Serum for Triple or Quad Marker
White (AFP Median)African American (AFP Median)Hispanic (AFP Median)Asian (AFP Median)
Low riskLess than 2 MoMLess than 2 MoMLess than 2 MoMLess than 2 MoM
MoM = multiples of the median. Serum values vary with maternal race, weight, weeks of gestation, diabetic status, and number of fetuses, and variations exist between test methods. Serial testing should be determined using the same test method.
Gestational Age (wk)HCG (Conventional Units)SI Units (Conventional Units × 1)
2 wk5–100 milli-international units/mL5–100 international units/L
3 wk200–3,000 milli-international units/mL200–3,000 international units/L
4 wk10,000–80,000 milli-international units/mL10,000–80,000 international units/L
5–12 wk10,000–200,000 milli-international units/mL10,000–200,000 international units/L
13–24 wk5,000–80,000 milli international units/mL5,000–80,000 international units/L
26–28 wk3,000–15,000 milli-international units/mL3,000–15,000 international units/L
Pregnancy-Associated Plasma Protein A
8 wk90–7,000 milli-international units/L
9 wk0–5,800 milli-international units/L
10 wk140–7,000 milli-international units/L
11 wk575–7,250 milli-international units/L
12 wk900–9,000 milli-international units/L
13 wk550–11,500 milli-international units/L
14 wk2,200–39,500 milli-international units/L
Unconjugated Estriol (E3) (Conventional Units)SI Units (Conventional Units × 3.467)
30 wk3.5–19 ng/mL12.1–65.9 nmol/L
34 wk5.3–18.3 ng/mL18.4–63.4 nmol/L
35 wk5.2–26.4 ng/mL18–91.5 nmol/L
36 wk8.2–28.1 ng/mL28.4–97.4 nmol/L
37 wk8–30.1 ng/mL27.7–104.4 nmol/L
38 wk8.6–38 ng/mL29.8–131.9 nmol/L
39 wk7.2–34.3 ng/mL25–118.9 nmol/L
40 wk9.6–28.9 ng/mL33.3–100.2 nmol/L
Results vary widely among laboratories and methods.HCG = human chorionic gonadotropin.

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Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Α1-Fetoprotein." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425272/all/α1_Fetoprotein.
Bladh ML, Van Leeuwen AM. Α1-Fetoprotein. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425272/all/α1_Fetoprotein. Accessed April 21, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Α1-Fetoprotein. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425272/all/α1_Fetoprotein
Bladh ML, Van Leeuwen AM. Α1-Fetoprotein [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 21]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425272/all/α1_Fetoprotein.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - α1-Fetoprotein ID - 425272 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425272/all/α1_Fetoprotein PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -