Apolipoproteins: A, B, and E

Apolipoproteins: A, B, and E is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
Apo A (Apo A1), Apo B (Apo B100), and Apo E.

Rationale
To identify levels of circulating lipoprotein to evaluate the risk of coronary artery disease (CAD).

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction. However, if the test is ordered in conjunction with a lipid profile or triglyceride level, instruct the patient to abstain from food for 6 to 12 hr before specimen collection.

Normal Findings
Method: Immunonephelometry for Apo A and Apo B; polymerase chain reaction (PCR) with restriction length enzyme digestion and polyacrylamide gel electrophoresis for Apo E.


Apolipoprotein A-1
AgeConventional UnitsSI Units (Conventional Units × 0.01)
Newborn38–106 mg/dL0.38–1.06 g/L
Child60–150 mg/dL0.6–1.5 g/L
Adult
 Male81–166 mg/dL0.81–1.66 g/L
 Female80–214 mg/dL0.8–2.14 g/L

Apolipoprotein B
AgeConventional UnitsSI Units (Conventional Units × 0.01)
Newborn–5 yr11–31 mg/dL0.11–0.31 g/L
Child
 Male47–139 mg/dL0.47–1.39 g/L
 Female41–96 mg/dL0.41–0.96 g/L
Adult
 Male46–174 mg/dL0.46–1.74 g/L
 Female46–142 mg/dL0.46–1.42 g/L

Normal Apo E: Homozygous phenotype for e3/e3.

Critical Findings and Potential Interventions
N/A

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