Type your tag names separated by a space and hit enter

Antidepressant Drugs (Cyclic): Amitriptyline, Nortriptyline, Protriptyline, Doxepin, Imipramine

Antidepressant Drugs (Cyclic): Amitriptyline, Nortriptyline, Protriptyline, Doxepin, Imipramine is a topic covered in the Davis's Lab & Diagnostic Tests.

To view the entire topic, please or purchase a subscription.

Nursing Central is the award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Explore these free sample topics:

Nursing Central

-- The first section of this topic is shown below --

General

Synonym/Acronym:
Cyclic antidepressants: amitriptyline (Elavil, Endep, Etrafon, Limbitrol, Triavil); nortriptyline (Allegron, Aventyl HCL, Nortrilen, Norval, Pamelor); protriptyline (Vivactil); doxepin (Adapin, Co-Dax, Novoxapin, Sinequan, Triadapin); imipramine (Berkomine, Dimipressin, Janimine, Pertofrane, Presamine, SK-Pramine, Tofranil PM).

Common Use:
To monitor subtherapeutic, therapeutic, or toxic drug levels in evaluation of effective treatment modalities.

Specimen:
Serum collected in a red-top tube.

DrugRoute of AdministrationRecommended Collection Time
AmitriptylineOralTrough: immediately before next dose (at steady state)
NortriptylineOralTrough: immediately before next dose (at steady state)
ProtriptylineOralTrough: immediately before next dose (at steady state)
DoxepinOralTrough: immediately before next dose (at steady state)
ImipramineOralTrough: immediately before next dose (at steady state)

Normal Findings:
(Method: Chromatography for amitriptyline, nortriptyline, protriptyline, and doxepin; immunoassay for imipramine)

DrugTherapeutic Range Conventional UnitsConversion to SI UnitsTherapeutic Range SI UnitsHalf-Life (h)Volume of Distribution (L/kg)Protein Binding (%)Excretion
Amitriptyline125–250 ng/mLSI units = Conventional units × 3.6450–900 nmol/L20–4010–3685–95Hepatic
Nortriptyline50–150 ng/mLSI units = Conventional units × 3.8190–570 nmol/L20–6015–2390–95Hepatic
Protriptyline70–250 ng/mLSI units = Conventional units × 3.8266–950 nmol/L60–9015–3191–93Hepatic
Doxepin110–250 ng/mLSI units = Conventional units × 3.58394–895 nmol/L10–2510–3075–85Hepatic
Imipramine180–240 ng/mLSI units = Conventional units × 3.57643–857 nmol/L6–189–2360–95Hepatic

-- To view the remaining sections of this topic, please or purchase a subscription --

Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Antidepressant Drugs (Cyclic): Amitriptyline, Nortriptyline, Protriptyline, Doxepin, Imipramine." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425348/all/Antidepressant_Drugs__Cyclic_:_Amitriptyline__Nortriptyline__Protriptyline__Doxepin__Imipramine.
Bladh ML, Van Leeuwen AM. Antidepressant Drugs (Cyclic): Amitriptyline, Nortriptyline, Protriptyline, Doxepin, Imipramine. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425348/all/Antidepressant_Drugs__Cyclic_:_Amitriptyline__Nortriptyline__Protriptyline__Doxepin__Imipramine. Accessed April 21, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Antidepressant Drugs (Cyclic): Amitriptyline, Nortriptyline, Protriptyline, Doxepin, Imipramine. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425348/all/Antidepressant_Drugs__Cyclic_:_Amitriptyline__Nortriptyline__Protriptyline__Doxepin__Imipramine
Bladh ML, Van Leeuwen AM. Antidepressant Drugs (Cyclic): Amitriptyline, Nortriptyline, Protriptyline, Doxepin, Imipramine [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 21]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425348/all/Antidepressant_Drugs__Cyclic_:_Amitriptyline__Nortriptyline__Protriptyline__Doxepin__Imipramine.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Antidepressant Drugs (Cyclic): Amitriptyline, Nortriptyline, Protriptyline, Doxepin, Imipramine ID - 425348 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425348/all/Antidepressant_Drugs__Cyclic_:_Amitriptyline__Nortriptyline__Protriptyline__Doxepin__Imipramine PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -