Immunoglobulins A, D, E, G, and M

Immunoglobulins A, D, E, G, and M is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
IgA, IgD, IgG, and IgM.

Rationale
To quantitate immunoglobulins A, D, G, and M as indicators of immune system function, to assist in the diagnosis of conditions that result in deficient or excessive production of immunoglobulins; to investigate immune system disorders such as multiple myeloma. To assess IgE levels in order to identify the presence of an allergic or inflammatory immune response.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Nephelometry for IgA, IgD, IgG, and IgM. Immunoassay for IgE.

AgeConventional UnitsSI Units
IgA(Conventional Units × 0.01)
 Newborn1–4 mg/dL0.01–0.04 g/L
 1–9 mo2–80 mg/dL0.02–0.8 g/L
 10–12 mo15–90 mg/dL0.15–0.9 g/L
 2–3 yr18–150 mg/dL0.18–1.5 g/L
 4–5 yr25–160 mg/dL0.25–1.6 g/L
 6–8 yr35–200 mg/dL0.35–2 g/L
 9–12 yr45–250 mg/dL0.45–2.5 g/L
 Older than 12 yr40–350 mg/dL0.40–3.5 g/L
IgD(Conventional Units × 10)
 NewbornGreater than 2 mg/dLGreater than 20 mg/L
 AdultLess than 15 mg/dLLess than 150 mg/L
IgG(Conventional Units × 0.01)
 Newborn650–1,600 mg/dL6.5–16 g/L
 1–9 mo250–900 mg/dL2.5–9 g/L
 10–12 mo290–1,070 mg/dL2.9–10.7 g/L
 2–3 yr420–1,200 mg/dL4.2–12 g/L
 4–6 yr460–1,240 mg/dL4.6–12.4 g/L
 Greater than 6 yr650–1,600 mg/dL6.5–16 g/L
IgM(Conventional Units × 0.01)
 NewbornLess than 25 mg/dLLess than 0.25 g/L
 1–9 mo20–125 mg/dL0.2–1.25 g/L
 10–12 mo40–150 mg/dL0.4–1.5 g/L
 2–8 yr45–200 mg/dL0.45–2 g/L
 9–12 yr50–250 mg/dL0.5–2.5 g/L
 Greater than 12 yr50–300 mg/dL0.5–3 g/L
IgEConventional and SI Units
Less than 1 yrLess than 20 units/mL
2–4 yrLess than 85 units/mL
5–9 yrLess than 1500 units/mL
10 yr and olderLess than 160 units/mL
Values vary by method and instrument.

Critical Findings and Potential Interventions
N/A

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