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Pseudocholinesterase and Dibucaine Number

Pseudocholinesterase and Dibucaine Number is a topic covered in the Davis's Lab & Diagnostic Tests.

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General

Synonym/Acronym:
CHS, PCHE, AcCHS.

Common Use:
To assess for pseudocholinesterase deficiency to assist in diagnosing a congenital deficiency. Special attention must be given to results for preoperative patients because positive results indicate risk for apnea with use of succinylcholine as an anesthetic drug.

Specimen:
Plasma collected in a lavender-top (EDTA) tube. Serum collected in a red-top tube is also acceptable.

Normal Findings:
(Method: Spectrophotometry, kinetic)

TestConventional Units
Pseudocholinesterase
 Males3,334–7,031 units/L
 Females2,504–6,297 inits/L
Dibucaine NumberFraction (%) of Activity Inhibited
Normal homozygote79%–84%
Heterozygote55%–70%
Abnormal homozygote16%–28%

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Pseudocholinesterase and Dibucaine Number." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425394/all/Pseudocholinesterase_and_Dibucaine_Number.
Bladh ML, Van Leeuwen AM. Pseudocholinesterase and Dibucaine Number. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425394/all/Pseudocholinesterase_and_Dibucaine_Number. Accessed April 24, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Pseudocholinesterase and Dibucaine Number. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425394/all/Pseudocholinesterase_and_Dibucaine_Number
Bladh ML, Van Leeuwen AM. Pseudocholinesterase and Dibucaine Number [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 24]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425394/all/Pseudocholinesterase_and_Dibucaine_Number.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Pseudocholinesterase and Dibucaine Number ID - 425394 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425394/all/Pseudocholinesterase_and_Dibucaine_Number PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -