Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody

Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
Antinuclear antibodies (ANA), anti-DNA (anti-ds DNA), antiextractable nuclear antigens (anti-ENA, ribonucleoprotein [RNP], Smith [Sm], SS-A/Ro, SS-B/La), anti-Jo (antihistidyl transfer RNA [tRNA] synthase), and antiscleroderma (progressive systemic sclerosis [PSS] antibody, Scl-70 antibody, topoisomerase I antibody).

Rationale
To diagnose multiple systemic autoimmune disorders; primarily used for diagnosing systemic lupus erythematosus (SLE).

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Indirect fluorescent antibody for ANA and anticentromere; Immunoassay multiplex flow for anti-DNA, anti-ENA, anti-Scl-70, and anti-Jo-1.

ANA and anticentromere: Titer of 1:40 or less. Anti-ENA, anti-Jo-1, and anti-Scl-70: Negative. Reference ranges for anti-DNA, anti-ENA, anti-Scl-70, and anti-Jo-1 vary widely due to differences in methods, and the testing laboratory should be consulted directly.


Anti-DNA
NegativeLess than 5 international units
Indeterminate5–9 international units
PositiveGreater than 9 international units

Critical Findings and Potential Interventions
N/A

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