Antibodies, Antinuclear, Anti-DNA, Anticentromere, Antiextractable Nuclear Antigen, Anti-Jo, and Antiscleroderma

Antibodies, Antinuclear, Anti-DNA, Anticentromere, Antiextractable Nuclear Antigen, Anti-Jo, and Antiscleroderma is a topic covered in the Davis's Lab & Diagnostic Tests.

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General

Synonym/Acronym:
Antinuclear antibodies (ANA), anti-DNA (anti-ds DNA), antiextractable nuclear antigens (anti-ENA, ribonucleoprotein [RNP], Smith [Sm], SS-A/Ro, SS-B/La), anti-Jo (antihistidyl transfer RNA [tRNA] synthase), and antiscleroderma (progressive systemic sclerosis [PSS] antibody, Scl-70 antibody, topoisomerase I antibody).

Common Use:
To diagnose multiple systemic autoimmune disorders; primarily used for diagnosing systemic lupus erythematosus (SLE).

Specimen:
Serum collected in a red-top tube.

Normal Findings:
(Method: Indirect fluorescent antibody for ANA and anticentromere; Immunoassay multiplex flow for anti-DNA, ENA, Scl-70, and Jo-1)

ANA and anticentromere: Titer of 1:40 or less. Anti-ENA, Jo-1, and anti-Scl-70: Negative. Reference ranges for anti-DNA, anti-ENA, anti-Scl-70, and anti-Jo-1 vary widely due to differences in methods and the testing laboratory should be consulted directly.


Anti-DNA
NegativeLess than 5 international units
Indeterminate5–9 international units
PositiveGreater than 9 international units

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Citation

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TY - ELEC T1 - Antibodies, Antinuclear, Anti-DNA, Anticentromere, Antiextractable Nuclear Antigen, Anti-Jo, and Antiscleroderma ID - 425420 Y1 - 2017 PB - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425420/all/Antibodies__Antinuclear__Anti_DNA__Anticentromere__Antiextractable_Nuclear_Antigen__Anti_Jo__and_Antiscleroderma ER -