Cancer Markers

Cancer Markers is a topic covered in the Davis's Lab & Diagnostic Tests.

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α1-Fetoprotein, anaplastic lymphoma receptor tyrosine kinase gene (ALK), BRAC-1, BRAC-2, BRAF, carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), cancer antigen 15-3 (CA 15-3), cancer antigen 19-9 (CA 19-9), cancer antigen 27.29 (CA 27.29), epidermal growth factor receptor gene (EGFR), HCG, HE4, HER-2–Neu, KRAS, methylated Septin 9 DNA.

To identify the presence of various cancers, such as breast and ovarian, as well as to evaluate the effectiveness of cancer treatment.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Electrochemiluminometric immunoassay.

α1-Fetoprotein Males (Conventional Units)SI Units (Conventional Units × 1)Females (Conventional Units)SI Units (Conventional Units × 1)
Less than 1 mo0.5–16,387 ng/mL0.5–16,387 mcg/L0.5–18,964 ng/mL0.5–18,964 mcg/L
1–11 mo0.5–28.3 ng/mL0.5–28.3 mcg/L0.5–77 ng/mL0.5–77 mcg/L
1–3 yr0.5–7.9 ng/mL0.5–7.9 mcg/L0.5–11.1 ng/mL0.5–11.1 mcg/L
4 yr and olderLess than 6.1 ng/mLLess than 6.1 mcg/LLess than 6.1 ng/mLLess than 6.1 mcg/L
Values may be higher for premature newborns.
Smoking StatusConventional UnitsSI Units (Conventional Units × 1)
 SmokerLess than 5 ng/mLLess than 5 mcg/L
 NonsmokerLess than 2.5 ng/mLLess than 2.5 mcg/L
Conventional UnitsSI Units (Conventional Units × 1)
CA 125
 Less than 35 units/mLLess than 35 kilo units/L
CA 15-3
 Less than 25 units/mLLess than 25 kilo units/L
CA 19-9
 Less than 35 units/mLLess than 35 kilo units/L
CA 27.29
 Less than 38.6 units/mLLess than 38.6 kilo units/L
Greater than 5 milli-international units/mL in males or nonpregnant femalesGreater than 5 international units/L in males or nonpregnant females

Critical Findings and Potential Interventions

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