Bone Turnover Markers (BTM)
General
Synonym/Acronym:
- Bone resorption/destruction: NTx (collagen cross-linked N-telopeptide of type I collagen)
- Bone formation: Osteocalcin (bone GLA protein, BGP)
Rationale
To assist in identifying an imbalance in bone turnover and evaluate the effectiveness of treatment for osteoporosis.
Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction. As appropriate, provide the required urine collection container for NTX and specimen collection instructions.
Normal Findings
Method: Electrochemiluminescent immunoassay.
NTx(Collagen Cross-Linked N-Telopeptide of Type I Collagen) | |
7–9 yr | |
Male | 167–578 nmol bone collagen equivalents (BCE)/mmol creatinine |
Female | 201–626 nmol bone collagen equivalents (BCE)/mmol creatinine |
10–12 yr | |
Male | 152–505 nmol bone collagen equivalents (BCE)/mmol creatinine |
Female | 173–728 nmol bone collagen equivalents (BCE)/mmol creatinine |
13–15 yr | |
Male | 103–776 nmol bone collagen equivalents (BCE)/mmol creatinine |
Female | 38–515 nmol bone collagen equivalents (BCE)/mmol creatinine |
16–17 yr | |
Male | 34–313 nmol bone collagen equivalents (BCE)/mmol creatinine |
Female | 20–144 nmol bone collagen equivalents (BCE)/mmol creatinine |
Adult male | 21–83 nmol bone collagen equivalents (BCE)/mmol creatinine |
Adult female (premenopausal) | 17–94 nmol BCE/mmol creatinine |
Adult female (postmenopausal) | 26–124 nmol BCE/mmol creatinine |
Osteocalcin | ||
---|---|---|
Age and Sex | Conventional Units | SI Units (Conventional Units × 1) |
6 mo–6 yr | ||
Male | 39–121 ng/mL | 39–121 mcg/L |
Female | 44–130 ng/mL | 44–130 mcg/L |
7–9 yr | ||
Male | 66–182 ng/mL | 66–182 mcg/L |
Female | 73–206 ng/mL | 73–206 mcg/L |
10–12 yr | ||
Male | 85–232 ng/mL | 85–232 mcg/L |
Female | 77–262 ng/mL | 77–262 mcg/L |
13–15 yr | ||
Male | 70–336 ng/mL | 70–336 mcg/L |
Female | 33–222 ng/mL | 33–222 mcg/L |
16–17 yr | ||
Male | 43–237 ng/mL | 43–237 mcg/L |
Female | 24–99 ng/mL | 24–99 mcg/L |
Adult | ||
Male | 3–40 ng/mL | 3–40 mcg/L |
Female | ||
Premenopausal | 5–30 ng/mL | 5–30 mcg/L |
Postmenopausal | 9–50 ng/mL | 9–50 mcg/L |
Critical Findings and Potential Interventions
N/A
There's more to see -- the rest of this topic is available only to subscribers.
Citation
Van Leeuwen, Anne M., and Mickey Lynn. Bladh. "Bone Turnover Markers (BTM)." Davis's Lab & Diagnostic Tests, 10th ed., F.A. Davis Company, 2023. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425475/all/Bone_Turnover_Markers__BTM_.
Van Leeuwen AMA, Bladh MLM. Bone Turnover Markers (BTM). Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2023. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425475/all/Bone_Turnover_Markers__BTM_. Accessed November 11, 2024.
Van Leeuwen, A. M., & Bladh, M. L. (2023). Bone Turnover Markers (BTM). In Davis's Lab & Diagnostic Tests (10th ed.). F.A. Davis Company. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425475/all/Bone_Turnover_Markers__BTM_
Van Leeuwen AMA, Bladh MLM. Bone Turnover Markers (BTM) [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2023. [cited 2024 November 11]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425475/all/Bone_Turnover_Markers__BTM_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Bone Turnover Markers (BTM)
ID - 425475
A1 - Bladh,Mickey Lynn,
AU - Van Leeuwen,Anne M,
BT - Davis's Laboratory & Diagnostic Tests
UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425475/all/Bone_Turnover_Markers__BTM_
PB - F.A. Davis Company
ET - 10
DB - Nursing Central
DP - Unbound Medicine
ER -