Alpha1-Antitrypsin and Alpha1-Antitrypsin Phenotyping

Alpha1-Antitrypsin and Alpha1-Antitrypsin Phenotyping is a topic covered in the Davis's Lab & Diagnostic Tests.

To view the entire topic, please or purchase a subscription.

Nursing Central is the award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Explore these free sample topics:

Nursing Central

-- The first section of this topic is shown below --

Synonym/Acronym:
α1-antitrypsin: A1AT, α1-AT, AAT; α1-antitrypsin phenotyping: A1AT phenotype, α1-AT phenotype, AAT phenotype, Pi phenotype.

Rationale
To assist in the identification of chronic obstructive pulmonary disease (COPD) and liver disease associated with α1-antitrypsin (α1-AT) deficiency.

Patient Preparation
There are no food, fluid, or activity restrictions unless by medical direction. Oral contraceptives should be withheld 24 hr before the specimen is collected, although this restriction should first be confirmed with the health-care provider (HCP) ordering the test.

Normal Findings
Method: Rate nephelometry for α1-AT, isoelectric focusing/high-resolution electrophoresis for α1-AT phenotyping.

α1-Antitrypsin

AgeConventional UnitsSI Units (Conventional Units × 0.01)
Newborn124–348 mg/dL1.24–3.48 g/L
Child110–279 mg/dL1.1–2.79 g/L
Adult126–226 mg/dL1.26–2.26 g/L

α1-Antitrypsin Phenotyping

There are three major protease inhibitor phenotypes:

  • MM—Normal
  • SS—Intermediate; heterozygous
  • ZZ—Markedly abnormal; homozygous

The total level of measurable α1-AT varies with genotype. The effects of α1-AT deficiency depend on the patient's personal habits but are most severe in patients who smoke tobacco.

Critical Findings and Potential Interventions
N/A

-- To view the remaining sections of this topic, please or purchase a subscription --