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1. The grafting of living tissue from its normal position to another site or the transferring of an organ or tissue from one person to another. Organs and tissues successfully transplanted include the heart, lung, kidney, liver, pancreas, cornea, large blood vessels, tendon, cartilage, skin, bone, and bone marrow. Brain tissue has been implanted experimentally to treat Parkinson disease. The matching of histocompatibility antigens that differentiate one person's cells from another's helps prevent rejection of donated tissues. Cyclosporine, tacrolimus, corticosteroids, monoclonal antibodies, and other immunosuppressive agents have been approx. 80% effective in preventing rejection of transplanted organs for 2 or more years.
SEE: autotransplantation; SEE: graft; SEE: heart transplantation; SEE: organ donation; SEE: renal transplantation; SEE: replantation
Patients who have received organ transplants and who are maintained on immunosuppressant drugs should generally avoid vaccination with live, attenuated organisms unless these vaccinations are specifically approved by their health care providers. Inactive vaccines are usually preferable for these patients.
2. In dentistry, the transfer of a tooth from one alveolus to another.