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saccharomyces boulardii


Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

sak-a-roe-mye-seez boo-lar-dee

Trade Name(s)

  • Brewer's yeast
  • probiotics

Ther. Class.
anti irritable bowel syndrome agents

Common Uses

  • Treatment and prevention of diarrhea
  • Irritable bowel syndrome.


Saccharomyces boulardii is a non-pathogenic yeast used to colonize the gastrointestinal tract.

Therapeutic Effect(s):

Reduced number of bowel movements.


Absorption: Unknown

Distribution: Unknown

Metabolism and Excretion: Unknown

Half-life: Unknown


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Contraindicated in:

  • Hypersensitivity to yeast.

Use Cautiously in:

  • Pregnancy and lactation;
  • Immunocompromised patients (↑ risk of fungemia)

Adverse Reactions/Side Effects

GI: bloating, constipation, flatulence

Misc: fungemia, ↑ thirst

* CAPITALS indicate life-threatening.
Underline indicate most frequent.


Natural Drug Interaction

Antifungalsmay decrease effectiveness of Saccharomyces boulardii




PO: (Adults) 250–500 mg two to four times a day.


Capsules: 250 mg


  • Assess patient for abdominal distention, presence of bowel sounds, and usual pattern of bowel function.
  • Assess color, consistency, and amount of stool produced.

Lab Test Considerations:

Monitor CBC periodically during therapy.

Potential Diagnoses

  • Diarrhea (Indications)


  • PO: Administer as directed.

Patient/Family Teaching

  • Instruct patient to take as directed.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Resolution of diarrhea and decrease in number of loose stools.

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Quiring, Courtney, et al. "Saccharomyces Boulardii." Davis's Drug Guide, 16th ed., F.A. Davis Company, 2019. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii.
Quiring C, Sanoski CA, Vallerand AH. Saccharomyces boulardii. Davis's Drug Guide. 16th ed. F.A. Davis Company; 2019. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii. Accessed April 20, 2019.
Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2019). Saccharomyces boulardii. In Davis's Drug Guide. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii
Quiring C, Sanoski CA, Vallerand AH. Saccharomyces Boulardii [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2019. [cited 2019 April 20]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - saccharomyces boulardii ID - 109984 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - Davis's Drug Guide UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii PB - F.A. Davis Company ET - 16 DB - Nursing Central DP - Unbound Medicine ER -