Topical treatment of interdigital tinea pedis, tinea cruris and tinea corporis.
- Inhibits an enzyme necessary for ergosterol synthesis, required for fungal cell membranes.
- Antifungal action .
Resolution of dermal fungal infection.Spectrum:
Active against Trichyphyton rubrum and Epidermpophyton floccosum.
Absorption: Small amounts are systemically absorbed.
Protein Binding: >99%
Metabolism and Excretion: Unknown.
TIME/ACTION PROFILE (improvement/resolution of infection)
- None noted.
Use Cautiously in:
- OB: Lactation: Safety not established;
- Pedi: Safety and effectiveness not established.
Adverse Reactions/Side Effects
Derm: application site reactions
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
May inhibit the activity of the CYP2C19 enzymes.
Topical: (Adults) Interdigital tinea pedisApply to affected and surrounding areas once daily for two weeks; Tinea cruris and tinea corporisApply to affected and surrounding areas once daily for one week.
- Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.
- Consult health care professional for proper cleansing technique before applying medication.
- Topical: For Interdigital tinea pedis: Apply thin layer to cover affected area and approximately 1 inch of immediate surrounding area completely daily for 2 wk.
- For Tinea Cruris or Tinea Corporis: Apply thin layer to affected area and approximately 1 inch of immediate surrounding area daily for 1 wk.
- Avoid the use of occlusive wrappings or dressings unless directed by health care professional. Wash hands after application.
- Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes and vagina.
- Patients with athlete's foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
- Advise patient to report increased skin irritation or lack of response to therapy to health care professional.
- Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
- Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Decrease in skin irritation and resolution of infection.
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